Job Description

My client is an exciting and rapidly growing gene therapy startup at the forefront of innovation located in the South San Francisco who are currently undergoing an expansion due to recently securing a significant series A funding round. They are committed to revolutionizing the treatment landscape for genetic disorders and are seeking a dynamic and experienced individual to join their team as the to lead their Bioanalytical Assay Development activities at a Principal Scientist or Associate Director level, or possibly Director for exceptional candidates.

As the Associate Director of Bioanalytical Assays, you will play a crucial role in their bioanalytical efforts to assess the efficacy and safety of their platform for treatment of genetic liver and metabolic diseases. The incumbent will lead the development, validation, and execution of a variety of protein and cell-based metabolic and enzymatic assays to advance our therapeutic programs from the initial in vitro and in vivo proof of concept to IND-enabling studies. This position offers a unique opportunity to contribute to cutting-edge research and make a meaningful impact on the lives of patients.

Responsibilities

• Development and hands-on execution of the bioanalytical / biomarker strategy for multiple gene therapy programs.
• Oversee the development, validation and execution of a variety of enzyme-based metabolic assays and other biomarkers to evaluate the safety and efficacy of our targeted gene insertion.
• Collaborate and align with internal teams and partners to integrate and optimize new assay technologies and methodologies to advance therapeutic programs.
• Manage the work of others directly as well as in a matrixed structure to conduct rigorous science and deliver high quality data in a timely manner.
• Oversee group communication of study results to the project teams and to internal and external stake holders.
• Support evaluation of BD opportunities and patent filling
• Act as a scientific mentor and role model, supporting the Addition Therapeutics culture.
• Potentially oversee the preclinical program strategy and inform key decisions.

Qualifications

• PhD in Biochemistry, Cell or Molecular Biology or a related field with 10+ years of relevant experience or BS/MS with 20+ years of relevant experience in similar life sciences-related field.
• Expertise in protein quantification and enzymatic assays is required for this role.
• Demonstrated proficiency in advanced analytical techniques such as HPLC and familiarity with Mass Spectrometry.
• Proven track record of developing and executing bioanalytical/biomarker strategies for gene therapy programs, ideally in the RNA therapeutics space.
• Familiarity with regulatory requirements and quality standards (FDA, EMA) for bioanalytical testing in the context of gene therapy is a plus.
• Demonstrated ability to independently solve scientific problems using multiple technologies and approaches.
• Experience in developing and working with in vitro and in vivo models for liver or metabolic diseases.
• Experience in managing direct reports and setting team priorities. Strong leadership and interpersonal skills with a proven track record of leading cross-functional teams is a big plus.
• A self-motivated, driven individual with a passion to learn and can-do attitude.

Benefits

• Based in the Bay Area
• Competitive salary of $160-200,000 pa and extensive benefits package
• Progression opportunities – Chance to get on the ground floor with a well-funded and rapidly expanding Biotech
• Comprehensive health, dental, and vision insurance
• Stock options for eligible employees

If you are looking to take the next step in your career in the Biotech industry and you would like to know more about this role or the other opportunities we currently have on our books, please apply now with your CV to speak with our specialist Scientific Consultant William Ashbrook

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